First established at Northwestern University in 1974, the Robert H. Lurie Comprehensive Cancer Center is committed to being a national leader in the battle to overcome cancer. To this end, the Cancer Center is dedicated to scientific discovery, advancing medical knowledge, providing compassionate, state-of-the-art cancer care, and training the next generation of clinicians and scientists. The Bioinformatics Core Facility at the Robert H. Lurie Comprehensive Cancer Center is focused on collaboration and publication with Cancer Center members. The Core Facility consists of five faculty-level bioinformaticists with experienced and diverse computer programmers. The Core develops state of the art algorithms for pathway analysis, microarray analysis, and proteomics. Good software development practices are used for bioinformatics and computational analysis of DNAs, proteins, clinical trials and clinical informatics. We offer student interns with a broader choice of projects and a general perspective of information technology in science and healthcare; previous curriculum in biology is not necessary for the projects.