My house rules version of the popular GURPS RPG (including GULLIVER's rules for scalability and a home-brew magic system), ported to Python for playing as a CRPG. v0.1 will include a stand-alone combat system for running those tedious large combats, and an adventure game system reminicent of the old Gold Box D&D games, with random dungeon generation. The adventure game system will of course use the combat system, but I also want the combat system to be useful to someone who wants to run a mostly pen-and-paper game but doesn't want the hassle of running 80-character battles manually.
Built on top of: Python 2.5, PyGTK 2.10 (including PyCairo). May require you to install some Python stuff to run.